Journal
CELL METABOLISM
Volume 18, Issue 5, Pages 617-633Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2013.06.019
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Funding
- Cancer Research UK
- European Research Council
- Netherlands Organisation for Scientific Research
- Canadian Institutes of Health Research
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The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs.
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