Journal
CELL METABOLISM
Volume 18, Issue 4, Pages 533-545Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2013.09.004
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Funding
- National Institute on Aging, NIH
- Office of Dietary Supplements, NIH
- NIH [R01 DK075772, F30 DK093198]
- Institute de Salud Carlos III [CD07/00208]
- Consejeria de Salud, Junta de Andalucia, Spain [EF-0122/2010]
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Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kappa B activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS +/- resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.
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