Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 21, Issue 3, Pages 191-198Publisher
HUMANA PRESS INC
DOI: 10.1385/JMN:21:3:191
Keywords
inflammation; free radicals; mitochondria; cyclooxygenase; creatine; Parkinson's disease
Categories
Ask authors/readers for more resources
There is evidence that both inflammatory mechanisms and mitochondrial dysfunction contribute to Parkinson's disease (PD) pathogenesis. We investigated whether the cyclooxygenase 2 (COX-2) inhibitor rofecoxib either alone or in combination with creatine could exert neuroprotective effects in the 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine model of PD in mice. Both rofecoxib and creatine administered alone protected against striatal dopamine depletions and loss of substantia nigra tyrosine hydroxylase immunoreactive neurons. Administration of rofecoxib with creatine produced significant additive neuroprotective effects against dopamine depletions. These results suggest that a combination of a COX-2 inhibitor with creatine might be a useful neuroprotective strategy for PD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available