Journal
CELL METABOLISM
Volume 18, Issue 5, Pages 749-758Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2013.09.014
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Funding
- Japan Society for the Promotion of Science [21890142, 22-481, 23390251]
- Ministry of Education, Culture, Sports, Science and Technology in Japan [23118517]
- Mochida Memorial Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [22390346, 23390251, 21890142, 22118007] Funding Source: KAKEN
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Osteocytes act as mechanosensors to control local bone volume. However, their roles in the homeostasis of remote organs are largely unknown. We show that ablation of osteocytes in mice (osteocyte-less [OL] mice) leads to severe lymphopenia, due to lack of lymphoid-supporting stroma in both the bone marrow and thymus, and complete loss of white adipose tissues. These effects were reversed when osteocytes were replenished within the bone. In contrast, neither in vivo supply of T cell progenitors and humoral factors via shared circulation with a normal parabiotic partner nor ablation of specific hypothalamic nuclei rescued thymic atrophy and fat loss in OL mice. Furthermore, ablation of the hypothalamus in OL mice led to hepatic steatosis, which was rescued by parabiosis with normal mice. Our results define a role for osteocytes as critical regulators of lymphopoiesis and fat metabolism and suggest that bone acts as a central regulator of multiple organs.
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