4.8 Review

Beyond the Sympathetic Tone: The New Brown Fat Activators

Journal

CELL METABOLISM
Volume 17, Issue 5, Pages 638-643

Publisher

CELL PRESS
DOI: 10.1016/j.cmet.2013.02.020

Keywords

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Funding

  1. MINECO, Spain [SAF2011-23636]
  2. Generalitat de Catalunya
  3. BBSRC
  4. MRC
  5. MRC CORD
  6. European Commission, FP7-Health, BetaBat project
  7. BBSRC [BB/J009865/1] Funding Source: UKRI
  8. MRC [G0802051, MC_UU_12012/2, G0600717] Funding Source: UKRI
  9. Biotechnology and Biological Sciences Research Council [BB/J009865/1] Funding Source: researchfish
  10. British Heart Foundation [PG/12/53/29714] Funding Source: researchfish
  11. Medical Research Council [G0600717, MC_UU_12012/2, G0600717B, G0802051, MC_UU_12012/5/B] Funding Source: researchfish

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If we could avoid the side effects associated with global sympathetic activation, activating brown adipose tissue to increase thermogenesis would be a safe way to lose weight. The discovery of adrenergic-independent brown fat activators opens the prospect of developing this alternative way to efficiently and safely induce negative energy balance.

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