Journal
CELL METABOLISM
Volume 17, Issue 2, Pages 185-196Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2013.01.001
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Funding
- Targeted Proteins Research Program
- Global COE Research Program
- Translational Systems Biology and Medicine Initiative from the Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Funding Program for Next Generation World-Leading Researchers (NEXT Program) from the Cabinet Office, Government of Japan
- [20229008]
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Adiponectin is a fat-derived hormone whose reduction plays central roles in obesity-linked diseases including insulin resistance/type 2 diabetes and atherosclerosis. The cloning of Adiponectin receptors AdipoR1 and AdipoR2 has stimulated adiponectin research, revealing pivotal roles for AdipoRs in pleiotropic adiponectin actions, as well as some postreceptor signaling mechanisms. Adiponectin signaling has thus become one of the major research fields in metabolism and clinical medicine. Studies on AdipoRs will further our understanding of the role of adiponectin in obesity-linked diseases and shortened life span and may guide the design of antidiabetic and antiaging drugs with AdipoR as a target.
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