Journal
MICROVASCULAR RESEARCH
Volume 65, Issue 1, Pages 56-60Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0026-2862(02)00012-2
Keywords
tumor blood flow; temporal heterogeneities; mathematical modeling; tumor vascular permeability
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Tumor blood flow (TBF) plays a fundamental role in tumor growth and treatment, and is characterized by spatial and temporal heterogeneities. Here we show that the interstitial fluid pressure (IFP), which is higher in tumoral tissue than in normal tissue, coupled with the tumor microvascular pressure (MVP) and the higher permeability of tumoral vessels, can explain the sustained oscillatory behavior of TBF, observed in vivo. (C) 2003 Elsevier Science (USA). All rights reserved.
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