Journal
CELL METABOLISM
Volume 14, Issue 6, Pages 724-738Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2011.08.016
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Funding
- Swiss National Science Foundation (FNRS) [3100AO-108336/1]
- Asterion Foundation Chair
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The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes a type of glial cell have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a neurocentric view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.
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