Journal
CELL METABOLISM
Volume 14, Issue 2, Pages 161-172Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2011.07.001
Keywords
-
Categories
Funding
- China Natural National Science Foundation (NSFC) [30890033, 91019019]
- Chinese Ministry of Science and Technology [2011CB504206]
- Chinese Academy of Sciences (CAS) [KSCX2-EW-R-02, KSCX2-EW-J-15]
- [XDA01010303]
Ask authors/readers for more resources
Epigenetic modifications are thought to be important for gene expression changes during development and aging. However, besides the Sir2 histone deacetylase in somatic tissues and H3K4 trimethylation in germlines, there is scant evidence implicating epigenetic regulations in aging. The insulin/IGF-1 signaling (IIS) pathway is a major life span regulatory pathway. Here, we show that progressive increases in gene expression and loss of H3K27me3 on IIS components are due, at least in part, to increased activity of the H3K27 demethylase UTX-1 during aging. RNAi of the utx-1 gene extended the mean life span of C. elegans by 30%, dependent on DAF-16 activity and not additive in daf-2 mutants. The loss of utx-1 increased H3K27me3 on the Igf1r/daf-2 gene and decreased IIS activity, leading to a more naive epigenetic state. Like stem cell reprogramming, our results suggest that reestablishment of epigenetic marks lost during aging might help reset the developmental age of animal cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available