Journal
CELL METABOLISM
Volume 13, Issue 3, Pages 236-238Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2011.02.008
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Funding
- NEI NIH HHS [K08 EY018677, K08 EY018677-04] Funding Source: Medline
- NIDDK NIH HHS [R01 DK053105-11, R01 DK053105] Funding Source: Medline
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Insulin contributes to skeletal muscle glucose uptake by increasing blood flow and recruiting perfused capillaries. In this issue of Cell Metabolism, Kubota et al. (2011) show that deletion of IRS-2 in endothelial cells in mice causes impaired transcapillary insulin transport, decreased insulin-stimulated glucose uptake in muscle, and mild glucose intolerance.
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