The mouse as a useful model of tuberculosis

Like other animal models of tuberculosis, the mouse has provided a large amount of information that can be applied to understanding the disease process in infected humans. The model is particularly useful in providing information about the immune response, given the huge database of reagents now available, including antibodies to lymphocyte markers and the growing number of available gene disrupted mice, and the model is validated by the fact that multiple mechanisms discovered in the mouse such as the TH1 pathway and the Toll-like receptor system are similarly important in humans. The model also has its limitations, particularly in terms of the immunopathologic response, in which similar elements occur but are expressed somewhat differently. (C) 2003 Elsevier Science Ltd. All rights reserved.