Journal
CELL METABOLISM
Volume 12, Issue 3, Pages 207-208Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2010.08.010
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A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPAR gamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2. This endogenous CPA regulates PPAR gamma functions required for adipogenesis, glucose homeostasis, and vascular wall biology.
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