Journal
TUBERCULOSIS
Volume 83, Issue 6, Pages 367-371Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/S1472-9792(03)00071-4
Keywords
toll-like receptors; C3H mice; aerosol infection
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Funding
- NIAID NIH HHS [AI-40488] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI040488] Funding Source: NIH RePORTER
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Although various members of the pattern recognition Toll-like receptor (TLR) family have been implicated in host resistance to Mycobacterium tuberculosis infection, it remains unclear if the TLR4 receptor plays an important role. We demonstrate here that infection of TRL4-competent and TLR4-deficient mice on the C3 H inbred mouse strain background had similar outcomes, measured in terms of the course of the disease, cell accumulation patterns in the lungs, and lung histopathology. These data argue against a significant role for TLR4 in immunity to tuberculosis in the mouse model. (C) 2003 Elsevier Ltd. All rights reserved.
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