Journal
CELL METABOLISM
Volume 10, Issue 1, Pages 3-4Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2009.06.007
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Endocytosed cholesterol must be transferred from the environment (e.g., low-density lipoproteins) via the lysosomal system to the rest of the cell. In Niemann-Pick type C disease, this process fails. In a recent issue of Cell, Kwon et al. (2009) suggest how this transpires mechanistically by crystallizing a domain of a protein defective in this syndrome.
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