Journal
CELL METABOLISM
Volume 7, Issue 6, Pages 476-484Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2008.03.010
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Funding
- NHLBI NIH HHS [HL84624, P01 HL018974-29, P01 HL018974, R01 HL063887, HL63887, R01 HL084624-02, R01 HL084624, R01 HL063887-08, HL18974] Funding Source: Medline
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Essential hypertension has devastating effects on the brain, being the major cause of stroke and a leading cause of dementia. Hypertension alters the structure of cerebral blood vessels and disrupts intricate vaso-regulatory mechanisms that assure an adequate blood supply to the brain. These alterations threaten the cerebral blood supply and increase the susceptibility of the brain to ischemic injury as well as Alzheimer's disease. This review focuses on the mechanisms by which hypertension disrupts cerebral blood vessels, highlighting recent advances and outstanding issues.
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