Journal
CELL METABOLISM
Volume 8, Issue 3, Pages 182-183Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2008.08.004
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Membrane redox state is governed by the complex interplay between oxidation of unsaturated fatty acids and lipophilic antioxidants. In this issue of Cell Metabolism, Seiler et al. (2008) show that a lipid oxidase, 12/15-lipoxygenase, and a membrane antioxidant enzyme, glutathione peroxidase-4, interact to regulate a novel redox-dependent cell death pathway.
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