Journal
CELL METABOLISM
Volume 8, Issue 2, Pages 99-104Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2008.06.012
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Funding
- Wellcome Trust Funding Source: Medline
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Interventions that extend life span by moderately reduced nutrient intake are often referred to as dietary or calorie restriction. Its efficacy in many species has led to the conclusion that a single, evolutionarily conserved, molecular mechanism operates in all cases to extend life. Here we discuss examples of diet/genotype interactions that show a more complex mechanistic view is required and that mild dietary modifications can dramatically change the interpretation of model organism aging studies.
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