Journal
CELL METABOLISM
Volume 7, Issue 1, Pages 1-2Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2007.12.006
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Endocannabinoid/cannabinoid receptor signaling acts centrally and peripherally to govern appetite and energy balance. While system stimulation promotes eating and energy storage, receptor blockade can reduce food intake and facilitate weight loss. In this issue of Cell Metabolism, Addy et al. (2008) test the therapeutic antiobesity potential of taranabant, a cannabinoid 1 receptor inverse agonist.
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