Journal
CELL METABOLISM
Volume 7, Issue 1, Pages 5-6Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2007.12.002
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Elevated fatty acids promote inflammation and insulin resistance. In this issue of Cell Metabolism, Koveset al. (2008) explore a novel paradigm suggesting that beta-oxidation of fatty acids exceeding the capacity of the tricarboxylic acid cycle yields incomplete fat oxidation and mitochondrial distress, obligatory events in the pathogenesis of insulin resistance.
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