Journal
CELL HOST & MICROBE
Volume 24, Issue 2, Pages 208-+Publisher
CELL PRESS
DOI: 10.1016/j.chom.2018.07.006
Keywords
-
Categories
Funding
- NIAID, NIH [R01 AI091985, R01 A1099451]
- Sens&Micro LAB Project of Regione Puglia [15]
- University of Bari [AYR9D32]
- Intramural Research Programs of the NHLBI
- NIAID
Ask authors/readers for more resources
In enteric viral infections, such as those with rotavirus and norovirus, individual viral particles shed in stool are considered the optimal units of fecal-oral transmission. We reveal that rotaviruses and noroviruses are also shed in stool as viral clusters enclosed within vesicles that deliver a high inoculum to the receiving host. Cultured cells non-lytically release rotaviruses and noroviruses inside extracellular vesicles. In addition, stools of infected hosts contain norovirus and rotavirus within vesicles of exosomal or plasma membrane origin. These vesicles remain intact during fecal-oral transmission and thereby transport multiple viral particles collectively to the next host, enhancing both the MOI and disease severity. Vesicle-cloaked viruses are non-negligible populations in stool and have a disproportionately larger contribution to infectivity than free viruses. Our findings indicate that vesicle-cloaked viruses are highly virulent units of fecal-oral transmission and highlight a need for antivirals targeting vesicles and virus clustering.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available