Journal
CELL HOST & MICROBE
Volume 13, Issue 3, Pages 347-357Publisher
CELL PRESS
DOI: 10.1016/j.chom.2013.02.007
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology [23380028, 24113519, S1101035]
- Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN)
- Grants-in-Aid for Scientific Research [22580053, 24113519, 23380028, 24658045] Funding Source: KAKEN
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CERK1 is a lysine motif-containing plant pattern recognition receptor for chitin and peptidoglycan. Chitin recognition by OsCERK1 triggers rapid engagement of a rice MAP kinase cascade, which leads to defense response activation. How the MAP kinase cascades are engaged downstream of OsCERK1 remains obscure. Searching for host proteins that interact with Xoo1488, an effector of the rice pathogen Xanthomonas oryzae, we identified the rice receptor-like cytoplasmic kinase, OsRLCK185. Silencing OsRLCK185 suppressed peptidoglycan-and chitin-induced immune responses, including MAP kinase activation and defense-gene expression. In response to chitin, OsRLCK185 associates with, and is directly phosphorylated by, OsCERK1 at the plasma membrane. Xoo1488 inhibits peptidoglycan-and chitin-induced immunity and pathogen resistance. Additionally, OsCERK1-mediated phosphorylation of OsRLCK185 is suppressed by Xoo1488, resulting in the inhibition of chitin-induced MAP kinase activation. These data support a role for OsRLCK185 as an essential immediate downstream signaling partner of OsCERK1 in mediating chitin-and peptidoglycan-induced plant immunity.
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