Journal
CELL HOST & MICROBE
Volume 13, Issue 5, Pages 505-507Publisher
CELL PRESS
DOI: 10.1016/j.chom.2013.04.013
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The metazoan gut harbors microbial communities on its mucosal surfaces, yet the mechanisms by which gut immunity tolerates symbiotic and commensal bacteria while eliminating pathogens is insufficiently understood. In a recent Cell paper, Lee et al. (2013) show that bacterial uracil, not secreted by commensal bacteria, triggers dual oxidase-dependent immunity.
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