Journal
CELL HOST & MICROBE
Volume 12, Issue 3, Pages 266-275Publisher
CELL PRESS
DOI: 10.1016/j.chom.2012.08.005
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Funding
- Swiss National Science Foundation
- Swiss SystemsX.ch initiative
- iPhD Systems.X fellowship
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Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target cell-membrane permeability and consequent cellular outcome. The responses to these toxins are also extremely diverse due to multiple downstream effects of pore-induced changes in ion balance. Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection.
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