Journal
MEDICINAL RESEARCH REVIEWS
Volume 23, Issue 6, Pages 697-762Publisher
WILEY
DOI: 10.1002/med.10052
Keywords
albomycin; aminoglycosides; anthacycline; antibiotics; aureolic acid; bacitracin; bleomycin; cisplatin; function; gramicidin; ionophore; metalloantibiotics; quinolones; siderophore; streptonigrin; structure; tetracycline
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Although most antibiotics do not need metal ions for their biological activities, there are a number of antibiotics that require metal ions to function properly, such as bleomycin (BLM), streptonigrin (SN), and bacitracin. The coordinated metal ions in these antibiotics play an important role in maintaining proper structure and/or function of these antibiotics. Removal of the metal ions from these antibiotics can cause changes in structure and/or function of these antibiotics. Similar to the case of metalloproteins, these antibiotics are dubbed metalloantibiotics which are the title subjects of this review. Metalloantibiotics can interact with several different kinds of biomolecules, including DNA, RNA, proteins, receptors, and lipids, rendering their unique and specific bioactivities. In addition to the microbial-originated metalloantibiotics, many metalloantibiotic derivatives and metal complexes of synthetic ligands also show antibacterial, antiviral, and antineoplastic activities which are also briefly discussed to provide a broad sense of the term metalloantibiotics. (C) 2003 Wiley Periodicals, Inc.
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