Journal
NEWS IN PHYSIOLOGICAL SCIENCES
Volume 18, Issue -, Pages 222-225Publisher
NEWS IN PHYSIOLOGICAL SCIENCES
DOI: 10.1152/nips.01456.2003
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A common mechanism affecting Ca2+ sensitivity in skeletal muscle is the proximity of myosin heads with actin filaments, a function of myofilament lattice spacing and myosin head mobility with respect to the myosin filament. This is an important mechanism of pCa(50)(2+) modulation by length, pH, regulatory light-chain phosphorylation, and temperature.
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