Journal
HEART FAILURE REVIEWS
Volume 8, Issue 1, Pages 107-115Publisher
SPRINGER
DOI: 10.1023/A:1022155206928
Keywords
nitric oxide; endothelin; vascular tone; cardiovascular system; receptor antagonist; heart failure
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Nitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play important roles in vascular homeostasis. This review is focused on the role and reciprocal interactions between NO and ET-1 in health and diseases associated with endothelium dysfunction. We will also discuss the clinical significance of NO donors and drugs that antagonize ET receptors.
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