Journal
HEART FAILURE REVIEWS
Volume 8, Issue 1, Pages 47-54Publisher
SPRINGER
DOI: 10.1023/A:1022194921040
Keywords
nitric oxide; platelet function; myocardial infarction; reperfusion
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Platelets play an important role in physiologic hemostasis and pathologic thrombosis that complicate the course of vascular disorders. A number of platelet functions including adhesion, aggregation and recruitment are controlled by nitric oxide (NO) generated by platelets and the endothelial cells. Derangements in this generation may contribute to the pathogenesis of thrombotic complications of vascular disorders. The pharmacologic supplementation of the diseased vasculature with drugs releasing NO may help to restore the hemostatic balance.
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