Journal
CANCER AND METASTASIS REVIEWS
Volume 22, Issue 4, Pages 395-403Publisher
SPRINGER
DOI: 10.1023/A:1023781114568
Keywords
apoptosis; invasion; MAPK; metastasis; migration; proteinases
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Funding
- NCI NIH HHS [R01 CA 83964] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA083964] Funding Source: NIH RePORTER
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Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.
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