Journal
ANNUAL REVIEW OF MICROBIOLOGY
Volume 57, Issue -, Pages 203-224Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.57.030502.090851
Keywords
fatty acids; phospholipids; DNA replication; protein modification; phospholipid function
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI015650, R01AI015650] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI15650] Funding Source: Medline
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Phospholipids play multiple roles in bacterial cells. These are the establishment of the permeability barrier, provision of the environment for many enzyme and transporter proteins, and they influence membrane-related processes such as protein export and DNA replication. The lipid synthetic pathway also provides precursors for protein modification and for the synthesis of other molecules. This review concentrates on the phospholipid synthetic pathway and discusses recent data on the synthesis and function of phospholipids mainly in the bacterium Escherichia coli.
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