Journal
ANNUAL REVIEW OF MICROBIOLOGY
Volume 57, Issue -, Pages 641-676Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.57.030502.091033
Keywords
tuberculosis; latency; granuloma; virulence; macrophage
Categories
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL064550] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI036396, R21AI047744, R01AI047744] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL64550] Funding Source: Medline
- NIAID NIH HHS [AI 36396, AI 47744] Funding Source: Medline
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Pathogenic mycobacteria, including the causative agents of tuberculosis and leprosy, are responsible for considerable morbidity and mortality worldwide. A hallmark of these pathogens is their tendency to establish chronic infections that produce similar pathologies in a variety of hosts. During infection, mycobacteria reside in macrophages and induce the formation of granulomas, organized immune complexes of differentiated macrophages, lymphocytes, and other cells. This review summarizes our understanding of Mycobacterium-host cell interactions, the bacterial-granuloma interface, and mechanisms of bacterial virulence and persistence. In addition, we highlight current controversies and unanswered questions in these areas.
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