Journal
CELL DEATH AND DIFFERENTIATION
Volume 19, Issue 10, Pages 1573-1581Publisher
SPRINGERNATURE
DOI: 10.1038/cdd.2012.96
Keywords
cortex; microRNA; neurogenesis; development
Categories
Funding
- FNRS
- Fonds Leon Fredericq
- Fondation Medicale Reine Elisabeth
- Walloon excellence in lifesciences and biotechnology (WELBIO)
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MicroRNAs (miRNAs) are non-coding RNAs that promote post-transcriptional silencing of genes involved in a wide range of developmental and pathological processes. It is estimated that most protein-coding genes harbor miRNA recognition sequences in their 30 untranslated region and are thus putative targets. While functions of miRNAs have been extensively characterized in various tissues, their multiple contributions to cerebral cortical development are just beginning to be unveiled. This review aims to outline the evidence collected to date demonstrating a role for miRNAs in cerebral corticogenesis with a particular emphasis on pathways that control the birth and maturation of functional excitatory projection neurons. Cell Death and Differentiation (2012) 19, 1573-1581; doi:10.1038/cdd.2012.96; published online 3 August 2012
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