Journal
CELL DEATH AND DIFFERENTIATION
Volume 20, Issue 1, Pages 12-20Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2012.66
Keywords
selective autophagy; ALFY; p62; protein aggregates; BEACH domain
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Funding
- Research Council of Norway (RCN)
- Norwegian Cancer Society
- South-Eastern Norway Regional Health Authority
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Autophagy, a highly conserved lysosomal degradation pathway, was initially characterized as a bulk degradation system induced in response to starvation. In recent years, autophagy has emerged also as a highly selective pathway, targeting various cargoes such as aggregated proteins and damaged organelles for degradation. The key factors involved in selective autophagy are autophagy receptors and adaptor proteins, which connect the cargo to the core autophagy machinery. In this review, we discuss the current knowledge about the only mammalian adaptor protein identified thus far, autophagy-linked FYVE protein (ALFY). ALFY is a large, scaffolding, multidomain protein implicated in the selective degradation of ubiquitinated protein aggregates by autophagy. We also comment on the possible role of ALFY in the context of disease. Cell Death and Differentiation (2013) 20, 12-20; doi:10.1038/cdd.2012.66; published online 1 June 2012
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