4.7 Review

A quarter century of granzymes

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Human and mouse granzyme M display divergent and species-specific substrate specificities

Stefanie A. H. de Poot et al.

BIOCHEMICAL JOURNAL (2011)

Article Biochemistry & Molecular Biology

Mouse granzyme K has pro-inflammatory potential

L. T. Joeckel et al.

CELL DEATH AND DIFFERENTIATION (2011)

Article Biochemistry & Molecular Biology

Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation

L. Shi et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Biochemistry & Molecular Biology

Nucleophosmin Is Cleaved and Inactivated by the Cytotoxic Granule Protease Granzyme M during Natural Killer Cell-mediated Killing

Sean P. Cullen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Immunology

Ignition of p53 Bomb Sensitizes Tumor Cells to Granzyme K-Mediated Cytolysis

Guoqiang Hua et al.

JOURNAL OF IMMUNOLOGY (2009)

Review Medicine, Research & Experimental

Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma

Wendy Anne Boivin et al.

LABORATORY INVESTIGATION (2009)

Review Immunology

Death by a thousand cuts: Granzyme pathways of programmed cell death

Dipanjan Chowdhury et al.

ANNUAL REVIEW OF IMMUNOLOGY (2008)

Article Biochemistry & Molecular Biology

Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death

Denis Martinvalet et al.

Article Immunology

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

Sunil S. Metkar et al.

IMMUNITY (2008)

Article Biochemistry & Molecular Biology

Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor

Marguerite S. Buzza et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Immunology

NK cell protease granzyme M targets α-tubulin and disorganizes the microtubule network

Niels Bovenschen et al.

JOURNAL OF IMMUNOLOGY (2008)

Review Biochemistry & Molecular Biology

Mechanisms of granule-dependent killing

S. P. Cullen et al.

CELL DEATH AND DIFFERENTIATION (2008)

Article Biochemistry & Molecular Biology

Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin

J. Pardo et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Rheumatology

Antiangiogenic plasma activity in patients with systemic sclerosis

Mary Jo Mulligan-Kehoe et al.

ARTHRITIS AND RHEUMATISM (2007)

Article Biochemistry & Molecular Biology

Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis

Guoqiang Hua et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Granzyme K directly processes bid to release cytochrome c and endonuclease g leading to mitochondria-dependent cell death

Tongbiao Zhao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells

T. Zhao et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Cell Biology

Human and murine granzyme B exhibit divergent substrate preferences

Sean P. Cullen et al.

JOURNAL OF CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis

Carly R. K. Loeb et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

p53 is cleaved by caspases generating fragments localizing to mitochondria

BS Sayan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Cell Biology

Identification of α-tubulin as a granzyme B substrate during CTL-mediated apoptosis

IS Goping et al.

JOURNAL OF CELL SCIENCE (2006)

Article Immunology

Functional analysis of granzyme M and its role in immunity to infection

LI Pao et al.

JOURNAL OF IMMUNOLOGY (2005)

Article Biochemistry & Molecular Biology

Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin

MS Buzza et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Immunology

CTL secretory lysosomes: biogenesis and secretion of a harmful organelle

G Bossi et al.

SEMINARS IN IMMUNOLOGY (2005)

Article Biochemistry & Molecular Biology

Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates

BJ Rukamp et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)

Article Biochemistry & Molecular Biology

Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B

S Mahrus et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Granzyme M mediates a novel form of perforin-dependent cell death

JM Kelly et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Hematology

Cell death induced by granzyme C

H Johnson et al.

BLOOD (2003)

Article Biochemistry & Molecular Biology

HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A

ZS Fan et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Multidisciplinary Sciences

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK

DA Thomas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Multidisciplinary Sciences

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

D Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway

MJ Pinkoski et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Induction of rapid histone degradation by the cytotoxic T lymphocyte protease granzyme A

D Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Immunology

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members Bid and Bax

JA Heibein et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)

Review Biochemistry & Molecular Biology

Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors

CM Kam et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (2000)