Purinergic signaling along the renal tubule: The current state of play

ATP-sensitive P2 receptors have been described in all mammalian nephron segments. A reductionist approach has demonstrated purinergic control of renal transporters in cell lines and heterologous expression systems. This brief update focuses on what is known of these receptors in native nephron segments (excluding the glomerulus) and outlines recent advances and possible future directions.