Journal
CELL DEATH AND DIFFERENTIATION
Volume 17, Issue 9, Pages 1373-1380Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2010.80
Keywords
GST; inhibitors; apoptosis; cell differentiation; cancer; therapy
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Glutathione transferases (GSTs) are enzymes that catalyze the conjugation of glutathione (GSH) to a variety of electrophilic substances. Their best known role is as cell housekeepers engaged in the detoxification of xenobiotics. Recently, GSTs have also been shown to act as modulators of signal transduction pathways that control cell proliferation and cell death. Their involvement in cancer cell growth and differentiation, and in the development of resistance to anticancer agents, has made them attractive drug targets. This review is focused on the inhibition of GSTs, in particular GSTP1-1, as a potential therapeutic approach for the treatment of cancer and other diseases associated with aberrant cell proliferation. Cell Death and Differentiation (2010) 17, 1373-1380; doi:10.1038/cdd.2010.80; published online 2 July 2010
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