Journal
JOURNAL OF INVESTIGATIVE SURGERY
Volume 16, Issue 6, Pages 325-333Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08941930390249865
Keywords
apoptosis; FAS; pancreatitis
Categories
Funding
- National Institutes of Health
- Welch Foundation
- American Heart Association
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Acute pancreatitis results in many deaths each year. Our understanding of the pathophysiology is limited. To better understand the impact of apoptosis versus necrosis, we compared cerulein-induced pancreatitis is Fas-deficient (MRL lpr/lpr) versus Fas-sufficient (MRL +/+) mice. Average amylase values in Fas-deficient mice were substantially greater than in the Fas-sufficient mouse. Histoloty graded on edema, inflammation, vacuolization, and necrosis showed greater injury in the Fas-deficient mouse. This findings suggests that the Fas pathway is important in controlling cerulein-induced pancreatitis.
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