Journal
CELL DEATH AND DIFFERENTIATION
Volume 17, Issue 2, Pages 209-214Publisher
SPRINGERNATURE
DOI: 10.1038/cdd.2009.58
Keywords
microRNA; miR-10; miR-10a; Hox genes; cancer; 5 ' TOP
Categories
Funding
- EC [201102]
- Vilhelm Pedersen and Hustrus Foundation
- Danish National Research Foundation
- Danish Cancer Society
- Lundbeck Foundation
- Association for International Cancer Research
- Lundbeck Foundation [R31-2007-1447] Funding Source: researchfish
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The microRNA (miRNA) miR-10 family has attracted attention because of its conservation and the position of the miR-10 genes within the Hox clusters of developmental regulators. In several species, miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox transcripts. In addition, members of the miR-10 family are de-regulated in several cancer forms. Aside from acting in translational repression, miR-10 was recently found to bind a group of transcripts containing a terminal oligo-pyrimidine (TOP) motif and to induce their translation, thereby adding a new function to the miRNA repertoire. Cell Death and Differentiation (2010) 17, 209-214; doi: 10.1038/cdd.2009.58; published online 22 May 2009
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