Journal
CELL DEATH AND DIFFERENTIATION
Volume 16, Issue 12, Pages 1573-1581Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2009.137
Keywords
cell death; glycolysis; GAPDH; mitochondria; cancer
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Funding
- l'Association pour la Recherche sur le Cancer
- l'Agence Nationnal de la Recherche
- la Fondation de France
- Plan Nacional I + D [SAF2008-04974]
- U. S. National Institutes of Health
- contrat d'interface INSERM-CHU de Nice
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Growing evidence points to the fact that glucose metabolism has a central role in carcinogenesis. Among the enzymes controlling this energy production pathway, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is of particular interest. Initially identified as a glycolytic enzyme and considered as a housekeeping gene, this enzyme is actually tightly regulated and is involved in numerous cellular functions. Particularly intriguing are recent reports describing GAPDH as a regulator of cell death. However, its role in cell death is unclear; whereas some studies point toward a proapoptotic function, others describe a protective role and suggest its participation in tumor progression. In this study, we highlight recent findings and discuss potential mechanisms through which cells regulate GAPDH to fulfill its diverse functions to influence cell fate. Cell Death and Differentiation (2009) 16, 1573-1581; doi: 10.1038/cdd.2009.137; published online 25 September 2009
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