Journal
CELL DEATH AND DIFFERENTIATION
Volume 17, Issue 2, Pages 215-220Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2009.69
Keywords
microRNA; BCL2; CLL; apoptosis; miR15/16 cluster
Categories
Funding
- Ma'of fellowship
- NIH [R01DK079217]
- University of Texas
- Ladjevardian Regents Research Scholar Fund
Ask authors/readers for more resources
MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL. Cell Death and Differentiation (2010) 17, 215-220; doi:10.1038/cdd.2009.69; published online 5 June 2009
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available