Journal
CELL DEATH AND DIFFERENTIATION
Volume 16, Issue 1, Pages 57-69Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2008.130
Keywords
autophagy; immunity; infection
Categories
Funding
- NIH [R01 A10151367, T32 A1007520]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI051367] Funding Source: NIH RePORTER
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Autophagy is emerging as a central component of antimicrobial host defense against diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation, autophagy has other functions during infection such as innate and adaptive immune activation. As an important host defense pathway, microbes have also evolved mechanisms to evade, subvert, or exploit autophagy. Additionally, some fungal pathogens harness autophagy within their own cells to promote pathogenesis. This review will highlight our current understanding of autophagy in infection, focusing on the most recent advances in the field, and will discuss the potential implications of these studies in the design of anti-infective therapeutics.
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