Journal
CELL DEATH AND DIFFERENTIATION
Volume 15, Issue 7, Pages 1147-1152Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2008.57
Keywords
mitochondria; fusion; fission; Drp1; Fis1; Fzo1
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Funding
- NIGMS NIH HHS [R01 GM077875, R01-GM077875] Funding Source: Medline
- NINDS NIH HHS [R01 NS037402, R01 NS034175-12, R01 NS034175] Funding Source: Medline
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Maintenance of functional mitochondria requires fusion and fission of these dynamic organelles. The proteins that regulate mitochondrial dynamics are now associated with a broad range of cellular functions. Mitochondrial fission and fusion are often viewed as a finely tuned balance within cells, yet an integrated and quantitative understanding of how these processes interact with each other and with other mitochondrial and cellular processes is not well formulated. Direct visual observation of mitochondrial fission and fusion events, together with computational approaches promise to provide new insight.
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