Journal
NEUROTOXICITY RESEARCH
Volume 5, Issue 5, Pages 355-368Publisher
SPRINGER
DOI: 10.1007/BF03033155
Keywords
human umbilical cord blood; neural cell transplantation; central nervous system; hematopoietic cells; stem cells
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Cellular therapy is a compelling and potential treatment for certain neurological and neurodegenerative diseases as well as a viable treatment for acute injury to the spinal cord and brain. The hematopoietic system offers alternative sources for stem cells compared to those of fetal or embryonic origin. Bone marrow stromal and umbilical cord cells have been used in pre-clinical models of brain injury, directed to differentiate into neural phenotypes, and have been related to functional recovery after engraftment in central nervous system (CNS) injury models. This paper reviews the advantages, utilization and progress of human umbilical cord blood (HUCB) cells in the neural cell transplantation and repair field.
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