Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
Volume 19, Issue -, Pages 333-366Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.cellbio.19.110701.161425
Keywords
sorting; polarity; pump; channel; transporter
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Funding
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK017433] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM042136] Funding Source: NIH RePORTER
- NIDDK NIH HHS [DK17433] Funding Source: Medline
- NIGMS NIH HHS [GM42136] Funding Source: Medline
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In order to carry out their physiological functions, ion transport proteins must be targeted to the appropriate domains of cell membranes. Regulation of ion transport activity frequently involves the tightly controlled delivery of intracellular populations of transport proteins to the plasma membrane or the endocytic retrieval of transport proteins from the cell surface. Transport proteins carry signals embedded within their structures that specify their subcellular distributions and endow them with the capacity to participate in regulated membrane trafficking processes. Recently, a great deal has been learned about the biochemical nature of these signals, as well as about the cellular machinery that interprets them and acts upon their messages.
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