Journal
ANNUAL REVIEW OF PHYSIOLOGY
Volume 65, Issue -, Pages 531-542Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.65.042902.092424
Keywords
kidney; Na/Pi-cotransport; protein interactions; PDZ proteins; reabsorption; inorganic phosphate
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The physiological tuning and pathophysiological alterations of renal proximal reabsorption of inorganic phosphate can be ascribed to the net amount of the Na/Pi-cotransporter NaPi-IIa localized in the brush border membrane. The net amount of NaPi-Ha appears to be the result of an endocytotic rate regulated by a complex network of different protein kinases. New approaches demonstrated that NaPi-Ha is part of heteromeric protein complexes, organized by PDZ (postsynaptic protein PSD95, Drosophila junction protein Disc-large, tight junction protein ZO-1) proteins. Such complexes are thought to play important roles in the apical positioning and regulated endocytosis of NaPi-IIa and therefore such interactions have to be considered when explaining proximal phosphate ion reabsorption.
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