Journal
CELL CYCLE
Volume 13, Issue 3, Pages 353-357Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.27769
Keywords
colorectal cancer; cancer subtypes; consensus clustering; therapy resistance; MSI; CIMP; cetuximab; serrated pathway
Categories
Funding
- KWF Fellowship (Dutch Cancer Society)
- NHS
- Swiss National Science Foundation
Ask authors/readers for more resources
Recently we published two independent studies describing novel gene expression-based classifications of colorectal cancer (CRC). Notably, each study stratified CRC into a different number of subtypes: one reported 3 subtypes, whereas the second highlighted 5. Given that each ascribed clinical significance, distinctive biology, and therapeutic prognosis to the different subtypes, we sought to reconcile this apparent incongruity in subtype stratification of CRC, and to interrelate the results. To do so, we each evaluated the other's data sets and analytical methods and discovered that the subtypes and their classifiers are, in fact, clearly related to each other; indeed, the 5 subtype outcomes can be coalesced into the same three. In addition to presenting this clarification, we briefly discuss how both classification methods can be viewed within the broader literature on CRC subtypes, and potentially applied.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available