Journal
CELL CYCLE
Volume 13, Issue 9, Pages 1495-1500Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.28472
Keywords
bone marrow stromal cells; gene expression; heart failure; body mass index; extracellular matrix remodeling
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Funding
- Ministry of Education and Science of the Russian Federation [02.527.11.0007]
- European Commission [241558]
- Ministry of Health of the Russian Federation [K-32-NIR/111-3]
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It is proposed that patients with heart failure may have not only myocardial dysfunction, but also a reduced regenerative capacity of stem cells. However, very little is known about bone marrow stromal cell (BMSC) characteristics in heart failure and its comorbidities (obesity and/or diabetes). We hypothesized that metabolic alterations associated with the latter will be reflected in altered expression of key genes related to angiogenesis, inflammation, and tissue remodeling in patient-derived BMSCs. We found that BMSCs of heart failure patients with lower body mass index have enhanced expression of genes involved in extracellular matrix remodeling. In particular, body mass index < 30 was associated with upregulated expression of genes encoding collagen type I, proteases and protease activators (MMP2, MMP14, uPA), and regulatory molecules (CTGF, ITG beta 5, SMAD7, SNAIL1). In contrast, these transcript levels did not differ significantly between BMSCs from obese heart failure patients and healthy subjects. Comorbidities (including obesity and diabetes) are known to play role in heart failure progression rate and outcome of the disease. We thus suggest that key molecular targets identified in this study should become the target of the subsequent focused studies. In the future, these targets may find some use in the clinical setting.
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