Journal
BIOSTATISTICS
Volume 4, Issue 1, Pages 97-107Publisher
OXFORD UNIV PRESS
DOI: 10.1093/biostatistics/4.1.97
Keywords
cutpoints; receiver operating characteristic curve; Truncated Normal
Funding
- NIMH NIH HHS [R01 MH 41739, R01 MH 51338] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH041739, R01MH051338] Funding Source: NIH RePORTER
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This article presents a method for estimating the accuracy of psychological screening scales using receiver operating characteristic curves and associated statistics. Screening scales are typically semicontinuous within a known range with distributions that are nearly symmetric when the target condition is present and highly skewed when the condition is absent. We model screening scale outcomes using truncated normal distributions that accommodate these different distributional shapes and use subject-specific random effects to adjust for multiple assessments within individuals. Using the proposed model, we estimate the accuracy of the Symptom Checklist as a measure of major depression from a repeatedly screened sample of patients.
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