Journal
ANNUAL REVIEW OF PLANT BIOLOGY
Volume 54, Issue -, Pages 165-182Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.arplant.54.031902.134847
Keywords
Arabidopsis; protein degradation; ubiquitin; RUB1
Categories
Ask authors/readers for more resources
The COP9 signalosome (CSN) is a multiprotein complex that was initially identified in plants as a repressor of photomorphogenesis. It is now known to play major roles in several other developmental pathways, from auxin response to flower development. Furthermore, the COP9 signalosome shares homologies with the lid sibcomplex of the proteasome and is evolutionarily conserved from fission yeast to humans. It is important for the proper development of virtually all higher eukaryotes. In recent years, significant progress has been made in unraveling the molecular, cellular, and physiological mode of action of the COP9 signalosome. This review discusses our current understanding of the COP9 signalosome function with particular emphasis on its recently defined role in modulating a wide variety of cellular processes by regulating specific protein degradation events.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available