Journal
CELL CYCLE
Volume 12, Issue 1, Pages 51-66Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.23121
Keywords
chromatin organization; stem cells; cancer stem cells; DEK; heterochromatin
Categories
Funding
- Kirschstein National Research Service Award (NRSA) from the National Cancer Institute of the National Institutes of Health [F32CA139931]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health [K12HD051953]
- Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Research Scholars mentored career development award
- Center for Clinical and Translational Science and Training at the University of Cincinnati
- Faculty of Medicine, RWTH Aachen
- German Research Foundation (DFG)
- Public Health Service [CA115611-01, R01 CA116316]
- Department of Defense award [W81XWH-12-1-0194]
Ask authors/readers for more resources
Stem cells are essential for development and tissue maintenance and display molecular markers and functions distinct from those of differentiated cell types in a given tissue. Malignant cells that exhibit stem cell-like activities have been detected in many types of cancers and have been implicated in cancer recurrence and drug resistance. Normal stem cells and cancer stem cells have striking commonalities, including shared cell surface markers and signal transduction pathways responsible for regulating quiescence vs. proliferation, self-renewal, pluripotency and differentiation. As the search continues for markers that distinguish between stem cells, progenitor cells and cancer stem cells, growing evidence suggests that a unique chromatin-associated protein called DEK may confer stem cell-like qualities. Here, we briefly describe current knowledge regarding stem and progenitor cells. We then focus on new findings that implicate DEK as a regulator of stem and progenitor cell qualities, potentially through its unusual functions in the regulation of local or global chromatin organization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available