Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
Volume 19, Issue -, Pages 493-517Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.cellbio.19.110701.155609
Keywords
membrane fusion; intracellular trafficking; rab protein; SM protein; neurotransmitter release
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The SNARE superfamily has become, since its discovery approximately a decade ago, the most intensively studied element of the protein machinery involved in intracellular trafficking. Intracellular membrane fusion in eukaryotes requires SNARE (soluble N-ethylmaleinfide-sensitive-factor attachment protein receptor) proteins that form complexes bridging the two membranes. Although common themes have emerged from structural and functional studies of SNAREs and other components of the eukaryotic membrane fusion machinery, there is still much to learn about how the assembly and activity of this machinery is choreographed in living cells.
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